We are fascinated by the question of how cells divide to create two identical daughter cells. The division process (mitosis) requires a tightly choreographed sequence of steps that first sorts duplicate copies of the cell's DNA into identical sets of chromosomes, then separates the two sets of chromosomes towards opposite ends of the cell, and finally divides the cell down the middle so that each daughter receives a complete set of chromosomes. All of these steps involve the activity of critical regulatory protein molecules and one of the most important elements in the choreography of mitosis is the machinery that destroys each of these critical protein molecules in turn, in the right place and at the right time, to allow the cell to move onto the next step in the sequence.
We study the pathways that deliver cellular proteins to the proteolytic machinery, and how they target two important regulators of mitosis, Aurora A and Aurora B protein kinases.
The interactive and clickable word cloud is derived from abstracts of our publications.